Soundara Rubhan R¹,
Manisundaram S²,
¹Post graduate,
²Associate Professor of Physiology,
Government Medical College,
Cuddalore, Annamalai Nagar,
Chidambaram, Tamil Nadu, India.

Abstract

• Background: Elevated serum uric acid levels are associated with hypertension, heart failure, Diabetes, obesity, metabolic syndrome, stroke, chronic kidney disease and non-alcoholic fatty liver disease. Because of this mutual relationship between uric acid and other cardio vascular risk factors, serum uric acid may have an independent role in the development of coronary artery disease. The potential relationship between the uric acid and coronary artery disease remains a topic of controversy for many years.
• Aim: To estimate and compare serum uric acid levels among acute ST Elevation Myocardial infarction (STEMI) in-patients and healthy individuals.
• Materials and Methods: After receiving approval from the Institutional Ethical Committee, the study was conducted among40 patients with Acute STEMI ranging over an age group of 28-80 years diagnosed by Electrocardiograph and 40age and sex matched healthy controls attending the master health check-up department. Blood samples were taken on the day of admission. Serum uric acid levels were assessed according to the standard procedure uricase PAP method.
• Results: Mean serum uric acid level was higher significantly in those with Acute STEMI (7.12±1.8) than in the control group (5.72 ± 1.3 mg/dl: P=0.05).
• Conclusion: Serum uric acid levels were found to be elevated in acute STEMI patients compared to normal controls in our study. Elevated Serum uric acid may have a definite role in various pathologic processes such as increased oxidative stress, endothelial dysfunctions, and inflammation leading to coronary artery disease.

Keywords: coronary artery disease, myocardial infarction, serum uric acid, STEMI