Background: Thyroid hormone influences cardiac functions and vascular resistance. Any dysfunction in thyroid hormone synthesis will produce profound cardiovascular effects. Arterial hypertension is known to be frequently associated with hypothyroidism. Hypothyroidism mainly affects diastolic blood pressure (DBP), narrowing the pulse pressure (PP) which can alter the mean arterial pressure. This study intends to find the variations in systemic arterial pressure and also the association of TSH with it. Aim: To find the variations in systemic arterial pressure and mean arterial pressure in hypothyroidism and to find the association of TSH with it. Methodology: This cross-sectional study involved 30 clinically diagnosed hypothyroid patients recruited from Endocrinology OP, Tertiary care hospital, Chennai. Serum Thyroid-stimulating hormone levels were estimated in all the subjects. Arterial blood pressure was recorded in all the subjects in the sitting posture and the results obtained. The results were tabulated and analysed by applying Pearson correlation coefficient and student “t” test. Results: Our study showed that the diastolic pressure was elevated in study participants compared to systolic blood pressure and also there was narrowing of pulse pressure. Hence mean arterial pressure was also elevated. There was a statistically significant positive correlation between TSH and systemic arterial pressure and mean arterial pressure. Conclusion: Our study concludes that there is an association between serum TSH and systemic arterial pressure.