VOLUME 11 , ISSUE 1 ( January-June, 2023 ) > List of Articles
Mohit Nadar S, Jannath Hameeda Banu, Kannan Rammiah, Rathnavel Kumaran Murugesan
Keywords : Cardiac autonomic neuropathy, type 2 Diabetes Mellitus, silent myocardial infarction, Heart rate variability
Citation Information : S MN, Banu JH, Rammiah K, Murugesan RK. Evaluation of Autonomic Function in newly diagnosed Type 2 Diabetes Mellitus using Heart Rate Variability. 2023; 11 (1):14-20.
DOI: 10.5005/NJP-11056-11_01_03
License: CC BY-NC 4.0
Published Online: 01-06-2023
Copyright Statement: Copyright © 2023; NA
Introduction: Cardiovascular autonomic neuropathy (CAN) is a serious complication of type 2 diabetes mellitus (T2DM) which is often underdiagnosed. CAN constitutes the chief cause for silent myocardial infarction and sudden death in type 2 diabetes mellitus patients. Heart Rate Variability (HRV) is a sensitive and non-invasive tool to assess the autonomic functions. Aim: To evaluate the effectiveness of heart rate variability as a tool to assess the autonomic functions in newly diagnosed T2DM patients. Methodology: 30 newly diagnosed T2DM patients in the age group of 18 – 45 years were recruited. ECG was recorded for 20 minutes to determine the HRV at supine rest with eyes closed. Instantaneous heart rate at RR intervals were plotted using RMS 2.5.2 software. Results: There was a significant reduction in the values of SDNN (ms), RMSSD (ms), NN50 count, pNN50% (time domain measures) and HF (ms2) (frequency domain measure). LF (ms2) levels and LF/HF ratio were significantly elevated in T2DM patients. Conclusion: HRV could detect cardiac autonomic neuropathy in newly diagnosed T2DM cases in the earlier stages and hence HRV can be used as an investigative tool to assess CAN in T2DM patients.
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