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VOLUME 4 , ISSUE 1 ( January-June, 2016 ) > List of Articles

ORIGINAL RESEARCH ARTICLE

Antidiabetic effect of Brassica oleraceae var. gongylodes in Streptozotocininduced diabetic rats

Damel Lakshmi U, Kayalvizhi E, Manikandan B, Rupasri Dutt Roy, Priyadarshini G, Chandrasekhar M

Keywords : Brassica oleracea var. gongylodes, diabetes mellitus, antidiabetic activity, Wistar rats

Citation Information : U DL, E K, B M, Roy RD, G P, M C. Antidiabetic effect of Brassica oleraceae var. gongylodes in Streptozotocininduced diabetic rats. 2016; 4 (1):18-21.

DOI: 10.5005/NJP-11056-04_01_04

License: CC BY-NC 4.0

Published Online: 01-06-2016

Copyright Statement:  Copyright © 2016; NA


Abstract

Background: Type 2 diabetes mellitus is a metabolic disorder which affects the metabolism of carbohydrates, proteins and fats. Amongst plant foods with health benefits, crops from the family Brassicaceae have been the focus of numerous epidemiological and clinical studies as they are a good source of a variety of nutrients and health promoting phytochemicals. Since the medicinal value of Brassica oleracea var. gongylodes or kohlrabi was not yet familiar in the society, we aimed to focus on its antidiabetic and antioxidant properties in Streptozotocin-induced diabetic rats. Aim: To study the antidiabetic effect of Brassica oleracea var. gongylodes in Streptozotocin-induced diabetic rats. Materials and Methods: Eighteen male Wistar rats (150-200g) were divided into 3 groups of 6 animals each, as Group I: Control group (citrate buffer), Group II: Streptozotocin-induced diabetes (47 mg/kg body weight) and Group III: Streptozotocin-induced diabetes treated with Brassica oleracea var. gongylodes (800 mg/kg body weight). Results: In Group III, the fasting blood glucose level was significantly reduced (p<0.05) to 91mg/dl in the first week of study, when compared to Group I and II and was maintained for the entire 28 days of the treatment. Antioxidant enzymes levels were found to be significantly increased (p<0.05) in Group II. Conclusion: This study revealed that the fasting blood glucose level of male Wistar rats with Streptozotocin-induced diabetes treated with Brassica oleracea var. gongylodes was significantly reduced when compared to the controls and the Streptozotocininduced diabetic group. Further studies are required to confirm such effects in humans.


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  1. Sikarwar MS, Patil MB, Kokate CK, Sharma S, Bhat V. Antidiabetic activity of Nerium indicum leaf extract in Alloxan-induced diabetic rats. J Young Pharm 2009;1(4):340-45
  2. Jung HA, Karki S, Ehom NY, Yoon MH, Kim EJ, Choi JS. Anti-Diabetic and Anti-Inflammatory Effects of Green and Red Kohlrabi Cultivars (Brassica oleracea var. gongylodes). Prev Nutr Food Sci. 2014;19(4) 281-90.
  3. Huang D, Ou B, Prior RL. The chemistry behind antioxidant capacity assays. J Agric Food Chem. 2005; 53:1841.56
  4. Espin JC, Garcia-Conesa MT, Tomas-Barberan FA. Nutraceuticals: facts and fiction. Phyto Chem 2007;68:2986-3008
  5. Pods.dek A. Natural antioxidants and antioxidant capacity of Brassica vegetables: A review. LWT-Food. Sci Technol 2007; 40:1.11
  6. Sharma I, Aaradhya M, Kodikonda M, Naik PR. Antihyperglycemic, antihyperlipidemic and antioxidant activity of phenolic rich extract of Brassica oleraceae var gongylodes on streptozotocin induced Wistar rats. Springer Plus; 2015; 4:212.
  7. Shah MA, Sarker MMR, Gousuddin M, Antidiabetic Potential of Brassica Oleracea Var. Italica in Type 2 Diabetic Sprague Dawley (sd) Rats. International Journal of Pharmacognosy and Phytochemical Research; 2016; 8(3); 462-69
  8. Anitha T, Divyadharsini R, Studies on invitro antioxidant properties of Brassica vegetables, IJPCBS 2014; 4 (4): 1061-65
  9. Wan CW, Wong CN, Pin WK, Wong MH, Kwok CY, Chan RY, Yu PH, Chan SW, Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-α in hypercholesterolemic rats induced with a high-cholesterol diet. Phytother Res. 2013; 27(4):545-51.
  10. Survay NS, Ko EY, Upadhyay CP, Mi J, Park SW, Lee DH, Jung YS, Yoon DY, Hong SJ. Hypoglycemic Effects of Fruits and Vegetables in Hyperglycemic Rats for Prevention of Type-2 Diabetes. Kor J. Hort. Sci. Technol. 2010; 28(5):850-56.
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