VOLUME 6 , ISSUE 1 ( January-June, 2018 ) > List of Articles
Sowmya M
Keywords : alarmins, Danger-Associated Molecular Patterns, danger signals, inflammation
Citation Information : M S. Danger-Associated Molecular Patterns (DAMPs) - the endogenous alarm signals. 2018; 6 (1):43-46.
DOI: 10.5005/NJP-11056-06_01_08
License: CC BY-NC 4.0
Published Online: 01-06-2018
Copyright Statement: Copyright © 2018; NA
Danger-Associated Molecular Patterns (DAMPs), or alarmins, are increasingly gaining importance as mechanisms that mediate inflammation in the absence of infectious agents. These are endogenous molecules, produced either intracellularly or extracellularly. These are mainly constitutive substances which are necessary for the normal functioning of the cell, but during conditions of cellular insult or stress, they act as danger signals. It was recently shown that DAMPs can also directly sense and report damage occurring in live cells undergoing physiological stress, even without loss of subcellular compartmentalization. DAMPs have been found to play a role in the pathogenesis of various disorders like arthritis, atherosclerosis, lupus, Crohn's disease and many neoplastic diseases. Further research into this relatively new class of molecules can lead to the potential development of targeted and specific anti-inflammatory treatments.
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