Background: Diabetes mellitus is expected to increase from 425 million in 2017 to 629 million by 2045 worldwide. Diabetes mellitus diagnosed during childhood presents an increased risk of complications in an early and productive stage of life, leading to a reduction in mean life expectancy of 10 to 20 years which is especially prevalent in developing countries. Children and adolescents with Type 1 diabetes Mellitus are at a heightened risk for mental health issues, including diabetes distress, depression, anxiety, and disordered eating. Health-Related Quality of Life (HRQOL) is an essential health outcome in clinical trials and healthcare. Aim: To evaluate the quality of life in children and adolescents with Type 1 Diabetes Mellitus for an effective management using Pediatric Quality of Life Inventory (PedsQL) tool questionnaire. Materials and Methodology: This was a prospective study. After ethical approval, 60 subjects who qualify the inclusion criteria were enrolled. The PedsQL tool questionnaire were given separately to child and parent. The child self-report and parent proxy-report were obtained and the PedsQL 4.0 Generic Core Scales were calculated. Statisticalanalysis was done using paired student ‘t’ test. Results: The PedsQL score of children was 77.94 ± 15.59 and that of parents was 74.12 ± 17.78. There was a significant difference between the child's self-report and the parents'-proxy report. The p value was statistically significant (p =0.000). Conclusion: These findings emphasizes the importance of the psychosocial assessment and regular counselling to the children and adolescents with Type 1 DM which is a chronic disease along with their routine medical treatment which insists on good glycemic control.