Background: Type 2 diabetes mellitus is the most common non-communicable disease worldwide. It is known as a progressive metabolic disease which arises because of insulin resistance and impaired insulin secretion. The hallmark of type 2 diabetes mellitus is its microangiopathic complications. Oxidative stress is a key factor in pathological processes which are observed in type 2 diabetes mellitus. Platelet to lymphocyte ratio might be increased in type 2 diabetes mellitus due to chronic inflammation. Aim: To compare the platelet-to-lymphocyte ratio in the Type 2 diabetic group and the control group. Materials and methods: A cross sectional analytical study was conducted with 30 healthy volunteers as the control group and 30 type 2 diabetic individuals as the study group. The complete blood count was done and the platelet to lymphocyte ratio was calculated as the ratio of the platelet count to absolute lymphocyte count. Results: The data obtained were analyzed using Statistical Package for Social Sciences (SPSS) version 20. The mean platelet to lymphocyte ratio in control group was 105.919 ± 39.34 versus 132.192 ± 42.01 in type 2 diabetic group and was found to be statistically significant (p-value <0.05). Conclusion: The present study found that platelet to lymphocyte ratio was high in diabetic subjects than in control subjects which is statistically significant (p-value <0.05). Hence, during routine checkup the platelet to lymphocyte ratio should be checked for assessing the disease severity and to prevent atherosclerotic complications in type 2 diabetes mellitus.